General Hospital (GH) spoilers for Wednesday, November 5, 2025, indicate that Anna Devane is in danger. Meanwhile, Gio Palmieri is the voice of reason, and more. Read on for Soap Opera News’ breakdown of what’s coming up.
Next on General Hospital: Anna’s in Danger
Anna (Finola Hughes) just can’t shake the feeling that something’s not right. She can’t quite put her finger on it, but Britt (Kelly Thiebaud) and Nathan’s (Ryan Paevey) sudden “return from the dead” feels like more than just another Port Charles miracle.
Deep down, she suspects there’s something, or someone, much bigger pulling the strings. And that someone might just be Caesar Faison.
Determined to get to the truth, Anna turns to Jason (Steve Burton) and opens up to him. Maybe he can help her uncover what’s really going on? She admits she needs to know once and for all if Faison is still alive, and if he is, then she has to be the one to finish him.
But that determination might come at a price. In the new General Hospital promo for this week, danger is closing in fast. We see Anna getting into her car, unaware that someone’s watching. Moments later, a figure wearing a black glove chloroforms her.
Uh oh, looks like danger has caught Anna completely by surprise.
Felicia and Spinelli Meet with Nathan
Speaking of Nathan, it looks like he’s got a pretty busy day ahead. Felicia (Kristina Wagner) and Spinelli (Bradford Anderson) can’t help but worry about what his sudden return means for James (Gary James Fuller). The three meet up at Bobbie’s to have a chat.
Nathan starts to wonder if Felicia and Spinelli are trying to talk him out of pursuing custody, but whatever they discuss and whatever decision they reach, it ends on a positive note. By the time Felicia and Spinelli walk away, they both seem relieved.
In other GH spoilers for November 5, Gio (Giovanni Mazza) is the voice of reason, Alexis (Nancy Lee Grahn) supports Danny (Asher Antonyzyn), and Sonny (Maurice Benard) arranges a private meeting with Justine (Nazneen Contractor).
So, who do you think chloroforms Anna? Leave your thoughts and predictions below! For more General Hospital spoilers, check back often for updates on the latest drama via the weekly spoilers!
(Photo Credit: ABC/Disney.)
Need to Know – General Hospital Spoilers for November 5
GH spoilers reveal that Sonny arranges a private meeting with Justine, and more.
Someone sporting black gloves chloroforms Anna from behind.
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